Abyss: When Polyphemus is picked up instead of being converted into a locust, it grants all of Abyss's locusts the high damage up without suffering the tears down allowing Isaac to increase his damage rate substantially the more items he uses Abyss on.

If a tear kills an enemy and has left over damage, the tear travels on with the remaining damage.

Greatly increased damage: ( D a m a g e + 4 ) × 2.

Mom's Knife: The benefits of fruit cake still occur but are short lived due to the high damage of Mom's knife.

This combination can easily clear most rooms.

If Isaac stays in one room long enough the Ludovico tear will often fill the room with many stationary Trisagion tears that last until Isaac leaves the room.

The Ludovico Technique: The tear will cycle through different effects, based on Isaac's tear rate.

Isaac's Tears/ Tammy's Head/ Tear Detonator: Each tear will have its own tear effect.

This also includes the Sulfuric Acid effect to destroy rocks and enter secret rooms.

Finger!/ Technology 2: Each tick of the laser has a random effect, allowing it to rapidly afflict enemies with multiple status effects.

Mega, Sad Bombs, Scatter Bombs, Sticky Bombs) as well as tear effects. Fetus: Bombs pull their effects from bomb modifiers ( Bobby-Bomb, Bob's Curse, Bomber Boy, Butt Bombs, Glitter Bombs, Hot Bombs, Mr.

Brimstone: Each tick of brimstone has a random effect.

This means that Fruit Cake can occasionally give previews of synergies that are locked. Tear effects used in the pool of Fruit Cake do not need their base items unlocked in order to be used.

Transform enemies into Poop (similarly to E.

Teleport enemies to a random location in the room.

The tear must deal the final hit earlier hits do not flag enemies to drop the consumable on death.

Drop hearts/coins/ cards/ runes on kill.

The unique tear effects available to some wisps made by Book of Virtues can also be used by Fruit Cake.

Tiny Planet: There is no associated range up.

Proptosis : There is no associated damage multiplier, effectively decreasing damage dealt.

Polyphemus: Only the ability to pierce enemies on overkill damage is applied there is no associated damage bonus with the tear.

My Reflection: There is no associated shot speed up.

Ipecac: There is no associated damage up/poison effect/arcing.

Eye of Greed: Isaac will not lose coins from this effect occurring.

The following tear effects when generated by Fruit Cake work differently than that of the base item:

Binding of isaac rebirth seeds